Cefuzor 500, containing Cefuroxime 500 mg, is a second-generation cephalosporin antibiotic. Cefuroxime is used to treat a variety of bacterial infections. Here's an overview of its uses, mechanism of action, and important considerations:
Uses
Respiratory Tract Infections
Acute and chronic bronchitis
Pneumonia
Sinusitis
Pharyngitis and tonsillitis
Ear Infections
Otitis media
Urinary Tract Infections
Cystitis
Pyelonephritis
Skin and Soft Tissue Infections
Cellulitis
Erysipelas
Wound infections
Gonorrhea
Uncomplicated gonococcal infections
Lyme Disease
Early stage Lyme disease and prevention of late Lyme disease
Mechanism of Action
Cefuroxime works by inhibiting bacterial cell wall synthesis. It binds to and inactivates penicillin-binding proteins (PBPs) on the inner membrane of the bacterial cell wall, which leads to cell lysis and death. Its broad-spectrum activity covers a wide range of Gram-positive and Gram-negative bacteria.
Role in Therapy
Broad-Spectrum Antibiotic: Effective against both Gram-positive and Gram-negative bacteria.
Alternative to Penicillins: Used in patients who are allergic to penicillins but do not have an anaphylactic reaction to beta-lactams.
Specific Infections: Preferred choice for certain infections such as respiratory tract infections, uncomplicated gonorrhea, and Lyme disease.
Dosage and Administration
Adults: The typical dose is 250-500 mg taken twice daily.
Children: Dosing depends on the weight of the child and the severity of the infection.
Side Effects
Gastrointestinal disturbances (nausea, vomiting, diarrhea)
Allergic reactions (rash, pruritus, urticaria)
Blood disorders (leukopenia, neutropenia, eosinophilia)
Hepatic enzyme elevations
Rarely, severe allergic reactions like anaphylaxis
Contraindications and Precautions
Allergy: Contraindicated in patients with a known allergy to cefuroxime or other cephalosporins.
Renal Impairment: Dose adjustment may be necessary.
Pregnancy and Breastfeeding: Should be used during pregnancy and lactation only if clearly needed.
Drug Interactions
Probenecid: Can increase cefuroxime levels by decreasing renal excretion.
Antacids and H2-Receptor Antagonists: May reduce the absorption of cefuroxime.
Summary
Cefuroxime 500 mg is a versatile antibiotic used to treat a wide range of infections. Its effectiveness against various bacteria makes it a valuable option in many clinical situations. However, like all antibiotics, it should be used judiciously to avoid the development of antibiotic resistance. Always consult a healthcare professional for appropriate diagnosis and treatment.